Micron-scale swimming robots could deliver drugs
07 August 2012
When you’re just a few microns long, swimming can be difficult. At that size scale, the viscosity of water is more like that of honey, and momentum will not maintain forward motion.
Microorganisms, of course, have evolved ways to swim in spite of these challenges, but tiny robots haven’t quite caught up. Now a team of researchers at the Georgia Institute of Technology has used complex computational models to design swimming micro-robots that could overcome these challenges to carry cargo and navigate in response to stimuli such as light.
The researchers believe these simple micro-swimmers could rely on volume changes in novel materials known as hydrogels to move tiny flaps that will propel them. The micro-devices could be used in drug delivery, lab-on-a-chip microfluidic systems – and even as micro-construction robots working in swarms.
“We believe that our simulations will give experimentalists a reason to pursue development of these micro-swimmers to go beyond what is available now,” said Alexander Alexeev, an assistant professor in the George W. Woodruff School of Mechanical Engineering at Georgia Tech. “We wanted to demonstrate the principle of how robots this small could move by determining what is important and what would need to be used to build a real system.”
The simple swimmer designed by Alexeev and collaborators Hassan Masoud and Benjamin Bingham consists of a responsive gel body about ten microns long with two propulsive flaps attached to opposite sides. A steering flap sensitive to specific stimuli would be located at the front of the swimmer.
The responsive gel body would undergo periodic expansions and contractions triggered by oscillatory chemical reactions, oscillating magnetic or electric fields, or by cycles of temperature change. These expansions and contractions – the chemical swelling and de-swelling of the material – would create a beating motion in the rigid propulsive flaps attached to each side of the micro-swimmer. Combined with the movement of the gel body, the beating motion would move the micro-swimmer forward.
The trajectory of the micro-swimmer would be controlled by a flexible steering flap on its front. The flap would be made of a material that deforms based on changes in light intensity, temperature or magnetic field.
“The combination of these flaps and the oscillating body creates a very nice motion that we believe can be used to propel the swimmer,” said Alexeev. “To build a device that is autonomous and self-propelling at the micron-scale, we cannot build a tiny submarine. We have to keep it simple.”
Key to the operation of the micro-swimmer would be the latest generation of hydrogels, materials whose volume changes in a cyclical way. The hydrogels would serve as 'chemical engines' to provide the motion needed to move the device’s propulsive flaps. Such materials currently exist and are being improved upon for other applications.
“We are using the state-of-the art in materials science, changing the properties of the material,” explained Masoud, a Ph. candidate in the School of Mechanical Engineering. “We have combined the materials with the principles of hydrodynamics at the small scale to develop this new swimmer.”
As part of their modelling, the researchers examined the effects of flaps of different sizes and properties. They also studied how flexible the micro-swimmer’s body needed to be to produce the kind of movement needed for swimming.
“You can’t swim at the small scale in the same way you swim at the large scale,” Alexeev said. “There is no inertia, which is how you keep moving at the large scale. What happens at the small scale is counter-intuitive to what you expect at the large scale.”
The computational fluid modelling the researchers used allowed them to study a wide range of parameters in materials, oscillation rates and flexibility. What they learned, Alexeev said, will give experimentalists a starting point for actually building prototypes of the flexible gel robots.
The simple micro-swimmers were described July 23 in the online advance edition of the journal Soft Matter, published by the Royal Society of Chemistry in the United Kingdom.
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