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Optical mammography sheds new light on breast cancer

27 September 2012

New optical imaging technology could give doctors new ways to both identify breast cancer and monitor individual patients' response to initial treatment of the disease.

Image credit: Sergio Fantini, professor of biomedical engineering at Tufts University
Image credit: Sergio Fantini, professor of biomedical engineering at Tufts University

A five-year clinical study of the procedure, developed at Tufts University School of Engineering and funded by a $3.5 million grant from the National Institutes of Health, is now underway at the Tufts Medical Center in Boston.

The non-invasive technology uses near infrared (NIR) light to scan breast tissue, and then applies an algorithm to interpret that information. Differences in light absorption allow identification of water, fats, and oxygen-rich and oxygen-poor tissue, the primary structures in breast tissue.

"The consensus is that x-ray mammography is very good at detecting lesions but it's not as good at determining which suspicious lesions are really cancer," says Professor of Biomedical Engineering Sergio Fantini, who is leading the research effort. The Tufts NIR technique could complement standard mammography, particularly for women younger than 40 who may have dense breast tissue that tends to obscure detail in x-rays.

Because it does not use ionizing radiation, the NIR technique can be applied multiple times over a short period without risk of radiation exposure, Fantini notes. Another advantage of the technology is that, unlike other breast imaging methods, it can obtain functional real-time images of metabolic changes, such as levels of haemoglobin concentration and oxygenation.

Optical mammography is also more comfortable than traditional mammograms. The patient's breasts are only lightly compressed between two horizontal glass panels and then illuminated by NIR light. A specialised software program displays real-time images of the breast as the optical system scans back and forth. A light detector within the system displays the intensity of the NIR beam as it is transmitted through the breast.

By using an algorithm based on the optical information, the technology generates breast images using the intensity of the transmitted light. The images are displayed automatically and can be read soon after the procedure, as is the case with x-ray mammograms. The technology can be packaged into compact, portable and handheld devices, say the researchers.

Shown above is an optical mammography image of haemoglobin oxygenation of a duct carcinoma in situ, a breast cancer in the lining of the milk ducts that has not yet invaded nearby tissues. In this image, the boxed area corresponds to the cancer location and indicates lower values of haemoglobin oxygenation.

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